Novel Sequential Process from N-Methoxyamides and Vinyl Grignard Reagents: New Synthesis of β-Aminoketones
Arthur Gomtsyan*, Robert J. Koenig and Chih-Hung Lee
*Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, Illinois 60064
A. Gomtsyan, R. J. Koenig, C.-H. Lee, J. Org. Chem., 2001, 66, 3613-3616.
DOI: 10.1021/jo0057497
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Abstract
The use of readily available and stable Weinreb amides enables a mild and efficient sequential synthesis of β-aminoketones or their derivatives ( e.g., pyrazolines). The reaction proceeds in good to excellent yields for a variety of amides, vinyl Grignard reagents and N-nucleophiles.
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A. Gomtsyan, Org. Lett., 2000, 2, 11-13.
Key Words
Acylation, Amination, Weinreb Ketone Synthesis
ID: J42-Y2001
